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KMID : 0363220090470050576
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Korean Journal of Dermatology
2009 Volume.47 No. 5 p.576 ~ p.579
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Treatment of Acne with Isotretinoin in a Patient with Apert`s Syndrome
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Cha Sang-Hee
Kim Hei-Sung
Park Young-Min
Suh Byung-Kyu
Kim Hyung-Ok
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Abstract
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Apert’s syndrome is a rare autosomal dominant disease that’s characterized by craniosynostosis and severe syndactyly of both the hands and feet. It is caused by a mutation of the fibroblast growth factor receptor (FGFR) type-2 gene. The development of widespread acne, involving the face, chest, back and forearms, is a characteristic finding at puberty in Apert’s syndrome patients. The acne of Apert’s syndrome patients is generally resistant to conventional therapy, including topical agents and/or oral antibiotics, but it shows a good response to isotretinoin. We report here on a case of acne that was successfully treated with isotretinoin in a teenager with Apert’s syndrome.
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KEYWORD
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Acne, Apert`s syndrome, Isotretinoin
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